Chronic fatigue syndrome (CFS) is a serious, long-term illness that affects many body systems. Another name for it is myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). CFS can often make you unable to do your usual activities. Sometimes you may not even be able to get out of bed. Other common symptoms occur involving numerous body systems, and chronic pain is very common. When it begins suddenly, it often follows an episode of infectious-like symptoms or a known infection. More so, specifically viral infection. Post-viral fatigue syndrome (PVFS) or post-viral syndrome describes a type of chronic fatigue syndrome that occurs following a viral infection. The emergence of long COVID has sparked increased interest in ME/CFS, as the two conditions may share pathology, and a treatment for one may treat the other.
 
CFS may also occur after physical trauma such as a car accident or surgery. The majority of people with CFS have significant difficulty engaging in work, school, and family activities for extended periods of time. An estimated 75% are unable to work because of their illness, and about 25% are housebound or bedridden for long periods, often decades. Many people with CFS also experience strongly disabling chronic pain.
 
The most commonly diagnosed include fibromyalgia, irritable bowel syndrome, depression, anxiety, allergies, and chemical sensitivities.
 
This Biohack includes natural remedies for the main genes and pathways associated with Chronic Fatigue Syndrome (CFS) including the recommended summary compounds that have the ability to correct the expression of the genes and pathways involved.

Chronic Fatigue Syndrome (CFS) Biohack Genes & Pathways:
 
RNASEL Gene - Ribonuclease L (#1 Gene)
IL10 Gene - Interleukin 10
TLR4 Gene - Toll Like Receptor 4
NFKB1 Gene - Nuclear Factor Kappa B Subunit 1
M3 and M4 Muscarinic Acetylcholine Receptors
ADRB2 Gene - Adrenoceptor Beta 2.
CDK2 Gene - Cyclin Dependent Kinase 2
MAPK8 Gene - Mitogen-Activated Protein Kinase 8 (JNK)
BECN1 Gene - Beclin 1
CYCS Gene - Cytochrome C, Somatic
Caspases 3 (Protein Yama), 8, 9
XPO1 Gene - Exportin 1
IFNA1 Gene - Interferon Alpha 1
JAK–STAT signaling
Oligoadenylate Synthetase (OAS) Genes
HIF1A Gene - Hypoxia Inducible Factor 1 Subunit Alpha
NEU1 Gene - Neuraminidase 1
CD4 Gene - CD4 Molecule
CCR5 Gene - C-C Motif Chemokine Receptor 5
CXCR4 Gene - C-X-C Motif Chemokine Receptor 4
DNAJA2 Gene - DnaJ Heat Shock Protein Family (Hsp40) Member A2 (DNAJ)
HSPA5 Gene - Heat Shock Protein Family A (Hsp70) Member 5 (GRP78)
HSP90B1 Gene - Heat Shock Protein 90 Beta Family Member 1 (GRP94)
CANX Gene – Calnexin
CALR Gene – Calreticulin
P4HB Gene - Prolyl 4-Hydroxylase Subunit Beta (PDIA1/Protein Disulfide-Isomerase)
LMAN1 Gene - Lectin, Mannose Binding 1
C3 Gene - Complement C3
C5AR1 Gene - Complement C5a Receptor 1
MBL2 Gene - Mannose Binding Lectin 2
SYK Gene - Spleen Associated Tyrosine Kinase
ZAP70 Gene - Zeta Chain Of T Cell Receptor Associated Protein Kinase 70
SRC Gene - SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase
LCK Gene - LCK Proto-Oncogene, Src Family Tyrosine Kinase
LYN Gene - LYN Proto-Oncogene, Src Family Tyrosine Kinase
PTPN6 Gene - Protein Tyrosine Phosphatase Non-Receptor Type 6 (SHP-1)
PTPN11 Gene - Protein Tyrosine Phosphatase Non-Receptor Type 11 (SHP-2)
INPP5D Gene - Inositol Polyphosphate-5-Phosphatase D (SHIP)
PTPA Gene - Protein Phosphatase 2 Phosphatase Activator (PP2A)
RIGI Gene - RNA Sensor RIG-I
MAVS Gene - Mitochondrial Antiviral Signaling Protein
NLRP3 Inflammasome
IRF3 Gene - Interferon Regulatory Factor 3
CREBBP Gene - CREB Binding Protein
MYD88 Gene - MYD88 Innate Immune Signal Transduction Adaptor
TLR2 Gene - Toll Like Receptor 2
TLR3 Gene - Toll Like Receptor 3
TLR4 Gene - Toll Like Receptor 4
TLR7 Gene - Toll Like Receptor 7
TLR9 Gene - Toll Like Receptor 9
CARD11 Gene - Caspase Recruitment Domain Family Member 11 (Holy Gene)
BCL10 Gene - BCL10 Immune Signaling Adaptor (God's Vineyard Gene)
TNF Gene - Tumor Necrosis Factor
IL6 Gene - Interleukin 6
IL1B Gene - Interleukin 1 Beta
IL2 Gene - Interleukin 2
SLC6A4 Gene - Solute Carrier Family 6 Member 4 (Serotonin Transporter)
CRH Gene - Corticotropin Releasing Hormone
POMC Gene – Proopiomelanocortin
MAOA Gene - Monoamine Oxidase A
HTR1A Gene - 5-Hydroxytryptamine Receptor 1A
Glucocorticoid Receptor (NR3C1 Gene - Nuclear Receptor Subfamily 3 Group C Member 1)
IGF1 Gene - Insulin Like Growth Factor 1