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The PANS - PANDAS Biohack includes the related maladies of Obsessive-Compulsive Disorder (OCD), Tic Disorder (TICS), and Gilles De La Tourette Syndrome (GTS) – Tic Disorder, primarily.


Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is a clinical diagnosis given to children who have a dramatic – sometimes overnight – onset of neuropsychiatric symptoms including obsessions/compulsions or food restriction. They are often diagnosed with obsessive-compulsive disorder (OCD) or an eating disorder, but the sudden onset of symptoms separates PANS from these other disorders. In addition, they may have symptoms of depression, irritability, anxiety, and have difficulty with schoolwork.


Like PANS, children with Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infections (PANDAS) have an acute onset – within 2 to 3 days – of neuropsychiatric symptoms, specifically OCD or tics (involuntary, purposeless movements).


The proposed link between infection and these disorders is that an autoimmune reaction to infection produces antibodies that interfere with basal ganglia function, causing symptom exacerbations, and this autoimmune response results in a broad range of neuropsychiatric symptoms.


PANDAS patients test positive for a recent streptococcal infection, such as strep throat, perianal strep or scarlet fever. Like PANS patients, they also may suffer from uncontrollable emotions, irritability, anxiety and loss of academic ability and handwriting skills. Although PANDAS was identified as a medical syndrome more than a decade before PANS, it has been classified as a subset of PANS. To date, PANDAS is the only known subset of PANS.


Treatment for children suspected of PANDAS is generally the same as the standard treatments for Tourette syndrome (TS) and OCD.


Therefore, for the purposes of PANS/PANDAS we will dissect primarily three maladies including:


  • Obsessive-Compulsive Disorder (OCD)
  • Tic Disorder (TICS)
  • Gilles De La Tourette Syndrome (GTS) – Tic Disorder


Now, through Epigenetic Biohacking, you can take back control of your health! Science has now shown that every dis-ease known has a specific gene that isn't functioning at optimal range. It's not necessarily the blueprint passed down to you from your parents, rather, in 90% of cases, it's caused by some epigenetic factor such as pathogens, heavy metals, or toxins, for example. The good news is that, because of epigenetics, which is how your environment and lifestyle influence the expression of your genes, you can now reverse the negative expression of your genes through diet, lifestyle, and targeted supplementation thereby decreasing symptoms, and kick-starting the self-healing process.


This Biohack includes natural remedies for the main genes and pathways associated with PANS - PANDAS including the recommended summary protocol for them.

PANS - PANDAS Biohack Genes & Pathways:


  • DRD1 Gene - Dopamine Receptor D1
  • DRD2 Gene - Dopamine Receptor D2
  • CREBBP Gene - CREB Binding Protein
  • BDNF Gene - Brain Derived Neurotrophic Factor
  • DNAH7 Gene - Dynein Axonemal Heavy Chain 7
  • GRIN1 Gene - Glutamate Ionotropic Receptor NMDA Type Subunit 1
  • SLC6A4 Gene - Solute Carrier Family 6 Member 4
  • Signal Transduction SuperPath
  • HDAC6 Gene - Histone Deacetylase 6
  • Histone acetyltransferases (HATs)
  • Histone deacetylases (HDACs)
  • Bromodomain (BET)
  • Eukaryotic Translation
  • CFTR Gene - CF Transmembrane Conductance Regulator
  • Class A/1 (Rhodopsin-like receptors) SuperPath
  • CCKAR Gene - Cholecystokinin A Receptor
  • Transmission across Chemical Synapses SuperPath
  • DLG4 Gene - Discs Large MAGUK Scaffold Protein 4 (PSD-95)
  • Unblocking of NMDA receptors, glutamate binding and activation SuperPath
  • ERBB4 Gene - Erb-B2 Receptor Tyrosine Kinase 4
  • NRGN Gene – Neurogranin
  • CAMK2A Gene - Calcium/Calmodulin Dependent Protein Kinase II Alpha
  • CASK Gene - Calcium/Calmodulin Dependent Serine Protein Kinase
  • LRRC7 Gene - Leucine Rich Repeat Containing 7
  • ERBIN Gene - Erbb2 Interacting Protein
  • Nuclear receptors meta-pathway SuperPath
  • SLC6A2 Gene - Solute Carrier Family 6 Member 2
  • Signaling by Rho GTPases
  • MIR24-1 Gene - MicroRNA 24-1
  • DROSHA Gene - Drosha Ribonuclease III
  • DICER1 Gene - Dicer 1, Ribonuclease III
  • miRNA regulation of DNA damage response Pathway
  • ATM Gene - ATM Serine/Threonine Kinase
  • CHEK1 Gene - Checkpoint Kinase 1
  • AURKB Gene - Aurora Kinase B



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