The Eczema Biohack
 
A comprehensive 10,000+ word (64 page) PDF download that covers everything you need to know about the largest organ on the body, the skin. More importantly, which natural compounds are vital to address Eczema at its core!
  
31.6 million people (10.1%) in the U.S. have some form of eczema, and prevalence peaks during early childhood. It is estimated that 1 in 10 individuals will develop eczema during their lifetime, with prevalence peaking in early childhood.
 
Eczema, also called Dermatitis, or Atopic Dermatitis, is are terms for several different types of skin swelling. The word "atopic" indicates an association with allergies. Up to 60 percent of people with atopic dermatitis develop asthma or hay fever (allergic rhinitis) later in life, and up to 30 percent have food allergies. Atopic dermatitis is often the beginning of a series of allergic disorders, referred to as the "atopic march”. With a weak barrier function, the skin is less able to retain moisture and protect against bacteria, irritants, allergens and environmental factors.
 
In addition, Allergic Contact Dermatitis is also associated with Eczema. Development of these disorders typically follows a pattern, beginning with atopic dermatitis, followed by food allergies, then hay fever, and finally asthma. However, not all individuals with atopic dermatitis will progress through the atopic march, and not all individuals with one allergic disease will develop others. Individuals with atopic dermatitis have an increased risk of developing other conditions related to inflammation, such as inflammatory bowel disease, rheumatoid arthritis, and hair loss caused by a malfunctioning immune reaction (alopecia areata). They also have an increased risk of having a behavioral or psychiatric disorder, such as attention-deficit/hyperactivity disorder (ADHD) or depression. In a particular subset of individuals with atopic dermatitis, the immune system is unable to protect the body from foreign invaders such as bacteria and fungi (which is known as immunodeficiency). These individuals are prone to recurrent infections.
 
Most types cause dry, itchy skin and rashes on the face, inside the elbows and behind the knees, and on the hands and feet. Scratching the skin can cause it to turn red, and to swell and itch even more.
 
Eczema is not contagious. It is likely caused by both genetic and environmental factors. Eczema may get better or worse over time, but it is often a long-lasting disease. People with atopic dermatitis are at risk of developing food allergies, hay fever and asthma.
 
The most common type of eczema is atopic dermatitis. It is most common in babies and children, but adults can have it too. As children who have atopic dermatitis grow older, this problem may get better or go away. But sometimes the skin may stay dry and get irritated easily.
 
Now, through Epigenetic Biohacking, you can take back control of your health! Science has now shown that every dis-ease known has a specific gene that isn't functioning at optimal range. It's not necessarily the blueprint passed down to you from your parents, rather, in 90% of cases, it's caused by some epigenetic factor such as pathogens, heavy metals, or toxins, for example. The good news is that, because of epigenetics, which is how your environment and lifestyle influence the expression of your genes, you can now reverse the negative expression of your genes through diet, lifestyle, and targeted supplementation thereby decreasing symptoms, and kick-starting the self-healing process.
 
This Biohack includes natural remedies for the main genes and pathways associated with Eczema including the recommended summary compounds for them.

Eczema Biohack Genes & Pathways:
 
FLG Gene – Filaggrin
CSNK2A1 Gene - Casein Kinase 2 Alpha 1
TGM1 Gene - Transglutaminase 1
TGM2 Gene - Transglutaminase 2
IVL Gene – Involucrin
LORICRIN Gene - Loricrin Cornified Envelope Precursor Protein
ELANE Gene - Elastase, Neutrophil Expressed
S100A1 Gene - S100 Calcium Binding Protein A1
DSP Gene – Desmoplakin
Keratinization Pathway
PERP Gene - P53 Apoptosis Effector Related To PMP22
CASP14 Gene - Caspase 14
NLRP3 Inflammasome
IFNG Gene - Interferon Gamma
RIGI Gene - RNA Sensor RIG-I
TGFB1 Gene - Transforming Growth Factor Beta 1
CSF2 Gene - Colony Stimulating Factor 2 (GM-CSF)
CCL2 Gene - C-C Motif Chemokine Ligand 2 (MCP-1)
CCL27 Gene - C-C Motif Chemokine Ligand 27
CXCR3 Gene - C-X-C Motif Chemokine Receptor 3
ICAM1 Gene - Intercellular Adhesion Molecule 1
FN1 Gene - Fibronectin 1
ITGB2 Gene - Integrin Subunit Beta 2 (LFA-1)
FCER2 Gene - Fc Epsilon Receptor II (IgE-mediated receptor)
CD4 Gene - CD4 Molecule
TNF Gene - Tumor Necrosis Factor
IL1B Gene - Interleukin 1 Beta
IL2RB Gene - Interleukin 2 Receptor Subunit Beta
IL4 Gene - Interleukin 4
IL6 Gene - Interleukin 6
IL8 (CXCL8 Gene - C-X-C Motif Chemokine Ligand 8)
IL10 Gene - Interleukin 10
IL13 Gene - Interleukin 13
IL18 Gene - Interleukin 18
DEFB4A Gene - Defensin Beta 4A (Skin-Antimicrobial Peptide 1)
TLR2 Gene - Toll Like Receptor 2
TLR3 Gene - Toll Like Receptor 3
TLR4 Gene - Toll Like Receptor 4
TLR9 Gene - Toll Like Receptor 9
MBL2 Gene - Mannose Binding Lectin 2
NFKB1 Gene - Nuclear Factor Kappa B Subunit 1
JAK/STAT Signaling
AHR Gene - Aryl Hydrocarbon Receptor
NOD2 Gene - Nucleotide Binding Oligomerization Domain Containing 2
NLRP3 Gene - NLR Family Pyrin Domain Containing 3
MYD88 Gene - MYD88 Innate Immune Signal Transduction Adaptor
DOCK8 Gene - Dedicator Of Cytokinesis 8
ROCK Signaling
PIEZO1 Gene - Piezo Type Mechanosensitive Ion Channel Component 1
PIEZO2 Gene - Piezo Type Mechanosensitive Ion Channel Component 2
MARVELD2 Gene - MARVEL Domain Containing 2 (Tricellulin)
OCLN Gene – Occludin
CLDN4 Gene - Claudin 4
TJP1 Gene - Tight Junction Protein 1 (Zona Occludens 1 / ZO-1)
F11R Gene - F11 Receptor (Junctional Adhesion Molecule 1 / JAM1)
MPDZ Gene - Multiple PDZ Domain Crumbs Cell Polarity Complex Component (MUPP1)
Ceramides
CERK Gene - Ceramide Kinase
S1PR1 Gene - Sphingosine-1-Phosphate Receptor 1
SPHK1 Gene - Sphingosine Kinase 1
CPTP Gene - Ceramide-1-Phosphate Transfer Protein
IL31 Gene - Interleukin 31
OSM Gene - Oncostatin M
Innate Immune System Pathway
MIF Mediated Glucocorticoid Regulation
IL22 Gene - Interleukin 22
Cytokine Signaling in Immune system Pathway
DUSP4 Gene - Dual Specificity Phosphatase 4
ERK Signaling Pathway