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The Duchenne Muscular Dystrophy (DMD) Biohack


Duchenne muscular dystrophy (DMD) is caused by a malfunction in the gene for the protein dystrophin. It is the most common type of muscular dystrophy. The life expectancy is 26. Dystrophin is a protein that provides structural integrity in muscle cells. Dystrophin is responsible for connecting the actin cytoskeleton of each muscle fiber to the underlying basal lamina (extracellular matrix). Muscle fibers undergo necrosis and are ultimately replaced with adipose and connective tissue.


DMD causes progressive muscle weakness due to muscle fiber disarray, death, and replacement with connective tissue or fat. The voluntary muscles are affected first, especially those of the hips, pelvic area, thighs, calves. It eventually progresses to the shoulders and neck, followed by arms, respiratory muscles, and other areas. Fatigue is common.


Most men affected with DMD become essentially "paralyzed from the neck down" by the age of 21. Cardiomyopathy, particularly dilated cardiomyopathy, is common, seen in half of 18-year-olds. The development of congestive heart failure or arrhythmia (irregular heartbeat) is only occasional. In late stages of the disease, respiratory impairment and swallowing impairment can occur, which can result in pneumonia.


Non musculoskeletal manifestations of DMD occur. There is a higher risk of neurobehavioral disorders (e.g., ADHD), learning disorders (dyslexia), and non-progressive weaknesses in specific cognitive skills (in particular short-term verbal memory), which are believed to be the result of inadequate dystrophin in the brain. Disruption of the blood–brain barrier has been seen to be a noted feature in the development of DMD.


Now, through Epigenetic Biohacking, you can take back control of your health! Science has now shown that every dis-ease known has a specific gene that isn't functioning at optimal range. It's not necessarily the blueprint passed down to you from your parents, rather, in 90% of cases, it's caused by some epigenetic factor such as pathogens, heavy metals, or toxins, for example. The good news is that, because of epigenetics, which is how your environment and lifestyle influence the expression of your genes, you can now reverse the negative expression of your genes through diet, lifestyle, and targeted supplementation thereby decreasing symptoms, and kick-starting the self-healing process.


This Biohack includes natural remedies for the main genes and pathways associated with Duchenne Muscular Dystrophy (DMD) including the recommended summary protocol for them.

Duchenne Muscular Dystrophy (DMD) Biohack Genes & Pathways:


  • DMD Gene – Dystrophin
  • UTRN Gene – Utrophin
  • SNTA1 Gene - Syntrophin Alpha 1
  • MAPK12 Gene - Mitogen-Activated Protein Kinase 12
  • MYOD1 Gene - Myogenic Differentiation 1
  • ADAM Metallopeptidase Domain 12
  • SRF Gene - Serum Response Factor
  • CSNK2A1 Gene - Casein Kinase 2 Alpha 1
  • Dystrophin-Glycoprotein Complex
  • LAMA2 Gene - Laminin Subunit Alpha 2
  • DAG1 Gene - Dystroglycan 1
  • AGRN Gene – Agrin
  • MUSK Gene - Muscle Associated Receptor Tyrosine Kinase
  • SRC Gene - SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase
  • CDH1 Gene - Cadherin 1 (E-Cadherin)
  • CTNNB1 Gene - Catenin Beta 1 (Armadillo)
  • CTTN Gene – Cortactin
  • ABL1 Gene - ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase
  • RAC1 Gene - Rac Family Small GTPase 1
  • PTK2 Gene - Protein Tyrosine Kinase 2 (FAK)
  • MBL2 Gene - Mannose Binding Lectin 2
  • C3 Gene - Complement C3
  • SYK Gene - Spleen Associated Tyrosine Kinase
  • CALM1 Gene - Calmodulin 1
  • CALD1 Gene - Caldesmon 1
  • TPM1 Gene - Tropomyosin 1
  • ATP2A1 Gene - ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 1
  • Signaling by Rho GTPases (ROCK)
  • ARHGEF3 Gene - Rho Guanine Nucleotide Exchange Factor 3
  • YAP1 Gene - Yes1 Associated Transcriptional Regulator
  • LIMK1 Gene - LIM Domain Kinase 1
  • CFL1 Gene - Cofilin 1
  • CAV3 Gene - Caveolin 3
  • PPARGC1A Gene - PPARG Coactivator 1 Alpha (PGC-1α)
  • DTNA Gene - Dystrobrevin Alpha
  • AQP4 Gene - Aquaporin 4
  • Cell differentiation - expanded index SuperPath
  • MEF2D Gene - Myocyte Enhancer Factor 2D
  • miRNAs involvement in the immune response in sepsis Singleton SuperPath
  • IL10 Gene - Interleukin 10
  • THPO Gene – Thrombopoietin
  • Striated muscle contraction pathway SuperPath
  • TNNT3 Gene - Troponin T3, Fast Skeletal Type
  • MYH9 Gene - Myosin Heavy Chain 9
  • DREAM Repression and Dynorphin Expression SuperPath
  • CACNG4 Gene - Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 4
  • GFAP Gene - Glial Fibrillary Acidic Protein
  • VIM Gene – Vimentin
  • ACTB Gene - Actin Beta

Duchenne Muscular Dystrophy (DMD) Biohack

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